PRODUCTION OF PURIFIED FIBRINOGEN CONCENTRATE
نویسندگان
چکیده
منابع مشابه
Fibrinogen concentrate therapy in complex cardiac surgery.
OBJECTIVES Fibrinogen concentrate increasingly is used to treat coagulopathic bleeding in cardiac surgery although its effectiveness and safety have not been shown. The authors conducted a cohort study to quantify the effects of fibrinogen concentrate on postoperative blood loss and transfusion and the occurrence of adverse clinical events in complex cardiac surgery patients. DESIGN A cohort ...
متن کاملProposed fibrinogen standard material with purified fibrinogen for plasma fibrinogen measurement on coagulation analyser
A commercially available fibrinogen standard calibrated by a World Health Organization (WHO) reference material is widely used in Japan, and most clinical laboratories use the Clauss method for plasma fibrinogen measurement. However, a current issue in fibrinogen measurement is poor laboratory-to-laboratory variability. To improve the reliability of fibrinogen values and thereby solve the poor ...
متن کاملTheoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate
BACKGROUND We aimed to create a theoretical tool to model the effect of three haemostatic agents containing fibrinogen (therapeutic plasma, cryoprecipitate, and fibrinogen concentrate) on the patient's plasma fibrinogen level. METHODS A mathematical model was developed step-wise. The relationship between the amount of haemostatic agent and plasma fibrinogen level was plotted for each agent. A...
متن کاملIII. Fibrinogen concentrate: clinical reality and cautious Cochrane recommendation.
S. Kozek-Langenecker1*, D. Fries2, D. R. Spahn3 and K. Zacharowski4 1 Department of Anaesthesia and Intensive Care, Evangelical Hospital Vienna, Austria 2 Department of General and Surgical Critical Care Medicine, Medical University Innsbruck, Austria 3 Institute of Anaesthesiology, University and University Hospital Zurich, Switzerland 4 Department of Anesthesiology, Intensive Care Medicine an...
متن کاملFibrinogen concentrate does not suppress endogenous fibrinogen synthesis in a 24-hour porcine trauma model.
BACKGROUND Fibrinogen concentrate may reduce blood loss after trauma. However, its effect on endogenous fibrinogen synthesis is unknown. The authors investigated the effect of exogenous human fibrinogen on endogenous fibrinogen metabolism in a 24-h porcine trauma model. METHODS Coagulopathy was induced in 20 German Landrace pigs by hemodilution and blunt liver injury. Animals were randomized ...
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ژورنال
عنوان ژورنال: Russian journal of hematology and transfusiology
سال: 2019
ISSN: 2411-3042,0234-5730
DOI: 10.35754/0234-5730-2019-64-1-73-78